【產(chǎn)品名稱】 華蟾毒精
【英文別稱】 5b,20(22)-Bufadienolide-3b,16b-diol-14,15b-epoxy 16-acetate
【CAS號】 470-37-1
【檢測方式】高效液相色譜法HPLC≥98%
【規(guī)格】5mg 10mg 20mg 50mg 100mg 500mg 1g (可根據(jù)客戶需求包裝)
【鑒定方法】液相(HPLC)質(zhì)譜(Mass) 核磁(NMR)
【密度】 1.28g/cm3
【沸點】 595.4oC at 760 mmHg
【閃點】 199.4oC
【熔點】 222-223oC
【用法】色譜條件:以甲醇-水為流動相,梯度洗脫;流速為 1.0ml/min;檢測波長為 280nm(僅供參考)
【藥理藥效】 華蟾毒精具有抗腫瘤作用、強心作用、抗心律失常、鎮(zhèn)痛作用
【作用與用途】 本品用于含量測定、鑒別、藥理實驗、活性篩選等
【注意事項】 本品應在低溫下保存,長時間在暴露在空氣中,含量會有所降低
【生產(chǎn)單位】 成都普菲德生物技術(shù)有限公司
【質(zhì)量承諾】 非人為造成的產(chǎn)品質(zhì)量問題,我司負責退貨或者換貨(非購買方人為造成)
【溫馨提醒】 我司提供一切產(chǎn)品僅供科研、實驗室使用,不得用于注射、食用或其他用途
[1]. Zhang G, et al. Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells. Oncotarget. 2016 Mar 3.
[2]. Yu Y, et al. Immunomodulatory Effects of Cinobufagin on Murine Lymphocytes and Macrophages. Evid Based Complement Alternat Med. 2015;2015:835263.
[3]. Baek SH, et al. Cinobufagin exerts anti-proliferative and pro-apoptotic effects through the modulation ROS-mediated MAPKs signaling pathway. Immunopharmacol Immunotoxicol. 2015 Jun;37(3):265-73.
[4]. Jiun-Yih Yeh, et al. Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells. The ProstateVolume 54, Issue 2, pages 112–124, 1 February 2003
[5]. Yu CH, et al. Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells. Cancer Science, 2008, 99 (12): 2467-2476
[6]. Peng Bei, et al. Progress in study on basic and clinical application in treating liver cancer by Cinobufagin Injection. Drug Evaluation Research, 2011-01